In the healthy human heart, numerous mitochondrial and myofibril proteins undergo post-translational succinylation that is important for proper functioning. In cardiomyopathy, this succinylation is greatly reduced and contributes to the dysfunction seen in the failing heart.

Image produced for the cover of the Journal of Molecular and Cellular Cardiology. Based on the article "Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy" by Hadi Ali, et al. https://www.jmmc-online.com/article/S0022-2828(19)30387-6/fulltext